While sermorelin is generally considered safe and well-tolerated, long-term use of sermorelin injections can potentially lead to certain complications. These may include:
- Injection Site Reactions: Prolonged use of injections can cause persistent redness, swelling, or pain at the injection site.
- Carpal Tunnel Syndrome: Long-term elevation of growth hormone levels may lead to symptoms associated with carpal tunnel syndrome, such as numbness or tingling in the hands and fingers.
- Edema: Fluid retention, which can cause swelling in the extremities, is another possible side effect of sustained growth hormone stimulation.
- Insulin Resistance: Chronic use of sermorelin may affect glucose metabolism, potentially leading to insulin resistance or type 2 diabetes.
- Increased Risk of Cancer: There is ongoing debate and research about the potential risk of cancer associated with prolonged growth hormone therapy, as elevated levels of growth hormone can stimulate the growth of certain types of cells.